metaEvidence COVID-19 - living meta-analysis

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Treament	Trials
Treament	Trials	Statistically conclusive or suggested result	Inconclusive results	Uncertain results	Safety results
study description meta-analysis results	0	-	-	-	-
study description meta-analysis results	7 / 16	none	inconclusive results for: death D28; deaths; deaths (time to event analysis only); clinical deterioration; clinical improvement; clinical improvement (14-day); clinical improvement (time to event analysis only); death or ventilation; hospital discharge; mechanical ventilation; serious adverse events; superinfection	suggested 4.9-fold increase in radiologic improvement (14-day) but the degree if certainty is unassessable	-
study description meta-analysis results	1	none	inconclusive results for: deaths; clinical deterioration; clinical improvement; clinical improvement (14-day); clinical improvement (28-day); clinical improvement (7-day); clinical improvement (time to event analysis only); AE leading to drug discontinuation; serious adverse events; deep vein thrombosis; elevated liver enzymes; hyperbilirubinemia; pulmonary embolism; renal impairment	-	-
study description meta-analysis results	11 / 18	none	inconclusive results for: 14-days deaths; death D28; deaths; deaths (time to event analysis only); clinical deterioration; clinical improvement; clinical improvement (14-day); clinical improvement (28-day); clinical improvement (7-day); clinical improvement (time to event analysis only); mechanical ventilation; mechanical ventilation (time to event analysis only); viral clearance ; viral clearance by day 14; ICU admission; off oxygenation; serious adverse events; adverse events	-	-
study description meta-analysis results	1 / 2	none	inconclusive results for: death or transfer to ICU; clinical improvement (14-day); clinical improvement (28-day); ICU admission; recovery; acute kidney injury ; arrhythmia; elevated liver enzymes; Myocardial infarction ; venous thromboembolism	suggested 46 % decrease in death D28 but the degree if certainty is unassessable suggested 46 % decrease in deaths but the degree if certainty is unassessable suggested 2.9-fold increase in clinical improvement but the degree if certainty is unassessable	-
study description meta-analysis results	1 / 2	none	inconclusive results for: deaths	-	-
study description meta-analysis results	0	-	-	-	-
study description meta-analysis results	0	-	-	-	-
study description meta-analysis results	4 / 5	statistically conclusive 66 % increase in clinical improvement (time to event analysis only)	inconclusive results for: death D28; deaths; deaths (time to event analysis only); clinical improvement; clinical improvement (14-day); hospital discharge; mechanical ventilation; ICU admission; off oxygenation; superinfection	-	-
study description meta-analysis results	8 / 18	statistically conclusive 44 % increase in clinical improvement	inconclusive results for: deaths (time to event analysis only); clinical deterioration; clinical improvement (28-day); clinical improvement (time to event analysis only); death or ventilation; hospital discharge; mechanical ventilation; recovery; serious adverse events; superinfection; adverse events	suggested 52 % decrease in ICU admission but the degree if certainty is unassessable	4 % increase in death D28 with safety concern 6 % decrease in deaths with safety concern
study description meta-analysis results	3 / 6	none	inconclusive results for: deaths; deaths (time to event analysis only); clinical improvement; clinical improvement (14-day); clinical improvement (time to event analysis only); serious adverse events; adverse events	-	-
study description meta-analysis results	2	none	inconclusive results for: deaths; clinical improvement; Major thrombotic events or death; Major bleeding	-	-
study description meta-analysis results	1	none	inconclusive results for: deaths; Major bleeding; Thromboembolic events	-	-

Statistically conclusive: statistically significant with a strict control of overall risk of type 1 error (statistically demonstrated), does not take into account the risk of bias; suggested: nominally statistically significant but without a strict control of overall risk of type 1 error; inconclusive: not nominally statistically significant

Living meta-analysis and evidence synthesis of therapies for COVID19